Prevention Research Branch

Active Prevention Grants Portfolio

Primary Branch Program Announcement(s)

Studies that test empirically or etiologically derived or theory-driven hypotheses with the potential for developing new drug abuse and drug abuse related HIV prevention approaches (e.g., neurobiological, intra- and inter-personal emotional, cognitive, and social processes) and studies that examine features of prevention programs that may account for successful intervention outcomes (e.g., client, implementer, content, and context and their interactions).

Efficacy and Effectiveness Research

Randomized control or equivalent design studies that test (1) the efficacy of innovative theory-based or empirically derived prevention approaches using relatively small well defined and controlled samples and (2) the effectiveness of such approaches in controlled studies with larger more diverse samples in real world settings. Attention to factors that moderate or mediate program outcomes, including those related to service delivery, is essential.

Systems Research

Studies that take effective interventions to scale in existing or new service delivery systems to examine factors that affect program sustainability and dissemination, including the selection, adoption, adaptation, organization, management, financing and delivery of the prevention services.

Methodology

Methodological studies that consider the complex issues specified in the areas above, such as: missing data in randomized trials, intervention fidelity, and multi-level longitudinal analyses.