NIDA Genetic Consortium Meetings & Abstracts | National Institute on Drug Abuse (NIDA)

Welcome

The Genetics and Epigenetics Cross-Cutting Research Team of the National Institute on Drug Abuse invites you to attend the May 23-24, 2024 NIDA Genetics and Epigenetics Cross-Cutting Research Team Meeting at Natcher Auditorium on the NIH Campus in Bethesda, MD. This is an in-person meeting. We expect to have more than 215 scientific presentations.

Registration and Meeting support information

May 23 - Session 1 Concurrent Panels (9:30–10:45 a.m.) SCORCH Consortium: Single-cell Approaches to Define Intersections Between Substance Use Disorders and HIV Infection
Chair: Paul Kenny, Ph.D., Icahn School of Medicine at Mount Sinai
Time	First Name	Last Name	Email	Abstract Title
9:15 a.m. - 9:30 a.m.	Lauren	Wills	Lauren.Wills@mssm.edu	HIV infection enhances the addiction-related actions of opioids: Brain substrates and cellular mechanisms
9:30 a.m. - 9:45 a.m.	Dong-Wook	Kim	dongwook.kim@alleninstitute.org	Characterization of Single cell multiomic changes during chronic HIV infection and cocaine self-administration in mice
9:45 a.m. - 10:00 a.m.	Brian	Herb	bherb@som.umaryland.edu	Comparative single-cell multi-omic atlases of molecular adaptations associated with substance use and HIV infections in the prefrontal cortex and nucleus accumbens of humans, non-human primates, and rodents
10:00 a.m. - 10:15 a.m.	Raleigh	Linville	linville@mit.edu	Cellular taxonomy of the human and mouse striatum defines novel neuronal subtypes in opioid and antipsychotic action

The ABCD Study - A Rich Resource for Genetic and Epigenetic Research on the Predictors of Substance Use
Chairs:
Kimberly LeBlanc, Ph.D., National Institute on Drug Abuse
Pamela Madden, Ph.D. Washington University in St. Louis.
Time	First Name	Last Name	Email	Abstract Title
9:15 a.m. - 9:30 a.m.	Robert	Loughnan	rloughnan@ucsd.edu	Opportunities and Challenges in Studying Genetic Risk for Substance Abuse in the ABCD Study
9:30 a.m. - 9:45 a.m.	Hermine H.	Maes	hermine.maes@vcuhealth.org	Estimating twin heritability and environmental sources of variation in the ABCD Study.
9:45 a.m. - 10:00 a.m.	Jill	Rabinowitz	jr1919@rutgers.edu	Associations of Neural and Genetic Characteristics with Substance Use Risk in the Adolescent Brain Cognitive Development Study
10:00 a.m. - 10:15 a.m.	Alexander	Hatoum	ashatoum@wustl.edu	2.) Phenome Wide Association Study of Polygenic Risk Scores for Substance Use Disorders in The Adolescent Brain and Development Study

May 23 – Session 2 Concurrent Panels (1:45–3:00 p.m.) Leveraging the All of Us Biobank to Make Strides In Substance Use Disorder Genomics Research
Chairs:
Arpana Agrawal, Ph.D., Washington University in St. Louis
Daniel Jacobson, Ph.D., Oak Ridge National Laboratory
Time	First Name	Last Name	Email	Abstract Title
1:45 p.m. - 2:00 p.m.	Janitza L.	Montalvo-Ortiz	janitza.montalvo-ortiz@yale.edu	Accelerating psychiatric genetics research in Latin American populations: Consortia efforts and Novel findings
2:00 p.m. - 2:15 p.m.	Peter	Barr	peter.barr@downstate.edu	The impact of social and genetic risk factors on the onset of comorbid problems in persons with substance use disorders.
2:15 p.m. - 2:30 p.m.	Emma	Johnson	emma.c.johnson@wustl.edu	1.) Phenotypic and genomic relationships between chronic pain and substance use disorders in the All of Us biobank
2:30 p.m. - 2:45 p.m.	Rodney	Gabriel	ragabriel@health.ucsd.edu	Predicting Development of Opioid Use Disorder Among Chronic Pain Patients Using Genomics, Social, and Clinical Factors within the All of Us Research Dataset

Understanding the Role of NAc in Substance Use Disorder (SUD) Beyond the D1 and D2 Level
Chairs:
Yi Zhang, Ph.D., Boston Children's Hospital
Veronica Alvarez, Ph.D., National Institute of Mental Health
Time	First Name	Last Name	Email	Abstract Title
1:45 p.m. - 2:00 p.m.	Yi	Zhang	yzhang@genetics.med.harvard.edu	Identifying and characterizing neuron subtypes and circuits regulating SUD
2:00 p.m. - 2:15 p.m.	Mary Kay	Lobo	mklobo@som.umaryland.edu	Cell subtype transcriptional programs in cocaine intake and seeking behavior
2:15 p.m. - 2:30 p.m.	Ana-Clara	Bobadilla	ac.bobadilla@colostate.edu	Differential genetic expression within reward-specific ensembles in mice
2:30 p.m. - 2:45 p.m.	Veronica A.	Alvarez	alvarezva@mail.nih.gov	Transcriptomic Landscape of Compulsive-like Alcohol Drinking

May 23 – Short Talk Session 1 (3:00–4:00 p.m.)
Time	First Name	Last Name	Email	Abstract Title
3:00 p.m. - 3:05 p.m.	Elissa	Chesler	Elissa.Chesler@jax.org	Integrative mouse genetic analysis illuminates human GWAS of multiple substance use.
3:05 p.m. - 3:10 p.m.	Michael	Garvin	garvinmr@ornl.gov	Genetic Loci Associated with Cocaine Use Identified using Novel Approach to Detect Epistasis
3:10 p.m. - 3:15 p.m.	Vivek	Kumar	Vivek.Kumar@jax.org	Forward genetic screen of the KOMP2/IMPC resource identifies addiction mutants
3:15 p.m. - 3:20 p.m.	Zhana	Duren	zduren@clemson.edu	Inferring gene regulatory networks from single cell multiome data using atlas-scale external data
3:20 p.m. - 3:25 p.m.	John	Hernandez	john_hernandez@brown.edu	Single nuclei transcriptomics of the Drosophila mushroom body
3:25 p.m. - 3:30 p.m.	J Spencer	Hatfield	jshatfi@clemson.edu	Genome-wide Association Analysis of Cocaine Preference in Drosophila
3:30 p.m. - 3:35 p.m.	Sergei	Grigoryev	sag17@psu.edu	Cryo-electron tomography reveals the inner structure of nucleosome condensates in chromatin of epigenetically modified mouse retina
3:35 p.m. - 3:40 p.m.	Andy	Chen	andychen@iu.edu	Functional Screening of Regulatory Variants Combined with Genome-wide Association and Machine Learning Identifies Causal Regulatory Mechanisms Impacting Substance Use Disorders

May 24 - Session 3 Concurrent Panels (9:05–10:20 a.m.) RNA-binding Proteins and Post-transcriptional Gene Regulation in Addiction Disorders
Chairs:
Duan Liu, Ph.D., Mayo Clinic
Yunlong Liu, Ph.D., Indiana University
Time	First Name	Last Name	Email	Abstract Title
9:35 a.m. - 9:50 a.m.	Yunlong	Liu	yunliu@iu.edu	Roles of alternative splicing in alcohol use disorder
9:05 a.m. - 9:20 a.m.	Duan	Liu	liu.duan@mayo.edu	Neuron-specific RNA-binding Protein ELAVL2 and Post-transcriptional Gene Regulation in Substance Use Disorders
9:20 a.m. - 9:35 a.m.	Huiping	Zhang	huipingz@bu.edu	RNA N6-methyladenosine modifications in the mesolimbic dopamine system of subjects with alcohol use disorder
9:50 a.m. - 10:05 a.m.	Katie	Rothamel	krothamel@health.ucsd.edu	Advancing RBP Research: Scalable Tools for Protein-RNA Interaction Analysis

Computational Approaches Analyzing Big Healthcare Data Using Machine Learning And Other Tools To Identify Genetic, Phenotypic Risk Factors And Potential Medication Treatments For Substance Use Disorders or Co-Occurring Mental Health Conditions
Chairs:
Udi Ghitza, Ph.D., National Institute on Drug Abuse
Susan Wright Ph.D., National Institute on Drug Abuse.
Time	First Name	Last Name	Email	Abstract Title
9:05 a.m. - 9:20 a.m.	Rong	Xu	rxx@case.edu	Repurposing ketamine to treat cocaine use disorder: integration of artificial intelligence-based prediction, expert evaluation, clinical corroboration and mechanism of action analyses
9:20 a.m. - 9:35 a.m.	Roy	Perlis	RPERLIS@mgh.harvard.edu	Uses and misuses of machine learning for electronic health records
9:35 a.m. - 9:50 a.m.	Alexander	Hatoum	ashatoum@wustl.edu	3.) Machine learning Predictors of Substance Use disorder using Genetics Need Control for Ancestry
9:50 a.m. - 10:05 a.m.	Travis	Mallard	tmallard@mgh.harvard.edu	Characterizing the Genetic Architecture of Impulsivity and its Overlap with Substance Use and Psychopathology

May 24 – Session 4 Concurrent Panels (1:15–2:30 p.m.) Novel Methodologies to Untangle Transcriptional and Epigenetic Underpinnings of Substance Use Disorder.
Chairs:
Eric Nestler, M.D., Ph.D., Icahn School of Medicine at Mount Sinai
Ian Maze, Ph.D., Icahn School of Medicine at Mount Sinai
Time	First Name	Last Name	Email	Abstract Title
1:15 p.m. - 1:30 p.m.	Alexander	Smith	smitaw@musc.edu	A master regulator of opioid reward in ventral prefrontal cortex
1:30 p.m. - 1:45 p.m.	Tamara	Markovic	tamara.markovic@mssm.edu	Modulating levels of ∆FOSB alters nucleus accumbens medium spiny neurons activity to salient stimuli.
1:45 p.m. - 2:00 p.m.	Sasha	Fulton	slf2127@columbia.edu	Multi-omic single-nucleus characterization of orbitofrontal cortex after cocaine self-administration
2:00 p.m. - 2:15 p.m.	Kristen	Maynard	Kristen.maynard@libd.org	Multi-omic approaches for molecular mapping of reward circuitry in the human brain

Decoding the Web of Addiction: A Systems Biology and Network Analysis Perspective
Chairs:
Olivia Corradin, Ph.D., Massachusetts Institute of Technology
Sulggi Lee, M.D., Ph.D., University of California, San Francisco
Time	First Name	Last Name	Email	Abstract Title
1:15 p.m. - 1:30 p.m.	Julia (Kate)	Brynildsen	jbryn@seas.upenn.edu	Gene coexpression patterns predict opiate-induced brain-state transitions
1:30 p.m. - 1:45 p.m.	Ming-Fen	Ho	ho.mingfen@mayo.edu	Single cell transcriptomics reveals distinct transcriptional responses to oxycodone and buprenorphine by iPSC-derived brain organoids from patients with opioid use disorder
1:45 p.m. - 2:00 p.m.	Susan	Ribeiro	susan.pereira.ribeiro@emory.edu	Methamphetamine Use in People with HIV on Antiretroviral Therapy is Associated with Elevated Systemic Inflammation and HIV Reservoir Transcription
2:00 p.m. - 2:15 p.m.	Bo	Zhang	bzhang29@wustl.edu	Methamphetamine-induced region-specific transcriptomic and epigenetic changes in the brain of male rats

May 24 – Short Talk Session 2 (4:00–5:00 p.m.)
Time	First Name	Last Name	Email	Abstract Title
4:00 p.m. - 4:05 p.m.	Rahul	D'Mello	Rahul dmello@ohsu.edu	Prenatal THC Exposure Alters the Offspring Methylome, Neurodevelopment, and Emotional Behavior
4:05 p.m. - 4:10 p.m.	Anna	Leonard	anna.leonard@pennmedicine.upenn.edu	Alternative splicing in a mouse model of Oprm1 A118G
4:10 p.m. - 4:15 p.m.	Alice K.	Min	alice.min@mountsinai.org	Genetically Modified Human iPSC-Derived Microglia in a Chimeric Mouse Model for Studying CNS HIV-1 Infection and Drug Use
4:15 p.m. - 4:20 p.m.	Dongbing	Lai	dlai@iu.edu	Genome-wide meta-analyses of cross substance use disorders in European, African, and Latino ancestry populations
4:20 p.m. - 4:25 p.m.	Nana	Amissah	nanaamis@buffalo.edu	Genome wide association studies in heterogeneous stock rats identify links between cue-reactivity and cocaine motivation.
4:25 p.m. - 4:30 p.m.	Jason	Bubier	Jason.Bubier@jax.org	One of these things is not like the others: Genetic Variation in Morphine and Fentanyl Response in Mice.
4:30 p.m. - 4:35 p.m.	Drew D.	Kiraly	dkiraly@wakehealth.edu	Gut-brain signaling as a modulator of brain chromatin structure and gene expression in models of substance use disorder.
4:35 p.m. - 4:40 p.m.	Ying-Xian	Pan	yx.pan@rutgers.edu	2.) Mitigating adverse side effects of clinically used mu opioids by targeting exon 7-associated splice variants of the mu opioid receptor gene, Oprm1, without altering mu opioid analgesia in pain management

May 23 – Poster Session A (10:45 a.m.–12:15 p.m.)
Poster Number	First Name	Last Name	Email	Abstract Title
1	Hannah	Alton	hannah.alton@nih.gov	Revisiting the cannabinoid-opioid interaction hypothesis using conditional CB1 and µ opioid receptor knockout mice
2	Bradley E.	Aouizerat	bea4@nyu.edu	Piercing the veil of how substance use negatively impacts comorbidities in HIV
3	Babak	Baban	bbaban@augusta.edu	Epigenetic effects on substance abuse through immune re-modelling
4	Svitlana V.	Bach	svitlana.bach@libd.org	Molecular profiling of the human nucleus accumbens with spatial and single nucleus resolution
5	Jared	Bagley	jbagley@binghamton.edu	Polygenic risk for extreme cocaine intake associates with larger dopaminergic responses to cocaine in the nucleus accumbens of BXD inbred mice
6	Ludmila	Bakhireva	lbakhireva@salud.unm.edu	Diagnostic Utility of miRNA Signature in Umbilical Cord Blood for Identification of Severe Neonatal Opioid Withdrawal Syndrome
7	Britahny M.	Baskin	b.baskin@northeastern.edu	Spontaneously Hypertensive Rat substrains and the offspring of reciprocal F2 crosses exhibit differences in addiction risk traits and cocaine behavioral sensitivity
8	Malia	Bautista	maliarb@uci.edu	The Missing Lynx: The Role of Lynx2 in Nicotine Relapse
9	Andrew W.	Bergen	awbergen2@gmail.com	Stable Methadone Dose, Toxicology & Treatment Retention in New Jersey MAT
10	Aritra	Bhattacherjee	Aritra.Bhattacherjee@childrens.harvard.edu	A molecularly and spatially defined prefrontal cortical circuit regulating drug relapse
11	Jennifer	Blackburn	Jennifer.blackburn@yale.edu	Multiplex Cytokine Profiling and Single Nuclei RNAseq Reveal Anti-Inflammatory Changes Following Intravenous Δ-9 Tetrahydrocannabinol Administration Among Healthy Participants
12	Kenneth	Blum	drd2gene@Gmail.com	Preaddiction Phenotype is Associated with Dopaminergic Dysfunction: Pharmacogenomic Evidence from 88.8M GWAS-Based Samples
13	Kasey	Brida	kbrida@uab.edu	Reelin regulates striatal excitability & cocaine reward
14	Russell W.	Brown	brown1@etsu.edu	Underlying Mechanisms of the Effects of Nicotine in a Heritable Model of Drug Abuse Vulnerability in Psychosis
15	Jason	Bubier	Jason.bubier@jax.org	Host genetics, microbiome composition and addiction/addiction-related behavior in mice
16	Cali	Calarco	ccalarco@som.umaryland.edu	Regulation of gene expression in striatal input regions by cocaine self-administration
17	Rianne	Campbell	rcampbell@som.umaryland.edu	Cocaine-induced Changes in Gene Expression and Regulation within GABAergic Ventral Pallidum Cell Types
18	Nazzareno	Cannella	nazzareno.cannella@unicam.it	Long-access heroin self-administration induces region specific reduction of grey matter volume and microglia reactivity in NIH Heterogeneous Stock rats.
19	Lieselot	Carrette	lcarrette@health.ucsd.edu	Characterization of the whole-brain reactivity and functional connectome associated with analgesia through MOR and KOR agonism.
20	Luis FS	Castro-de-Araujo	luis.araujo@vcuhealth.org	Dynamic Growth of ADHD Symptoms in Youth: Estimating Variance Components of Latent Growth Factors and their Associations with Genetic Liabilities to Substance Use and Abuse
21	Samar Nasser	Chehimi	samar.chehimi@pennmedicine.upenn.edu	Fentanyl-xylazine interaction induces transcriptional modifications in the nucleus accumbens of Sprague Dawley rats
22	Hao	Chen	hchen@uthsc.edu	1.) Sex and heredity are determinants of oral oxycodone self-administration in 36 Inbred Rat Strains: correlations with behavioral tests of anxiety and novelty-seeking
23	Laurens	Holmes, Jr.	lholmes@desu.edu	1.) DNA Methylation of Candidate Genes (ACE II, IFN-γ, AGTR 1, CKG, ADD1, SCNN1B and TLR2) Implication in Substance Use Disorders (SUD) in Essential Hypertension
24	Youshu	Cheng	youshu.cheng@yale.edu	A hierarchical Bayesian interaction model to estimate cell-type-specific methylation quantitative trait loci incorporating priors from cell-sorted bisulfite sequencing data
25	Meghan	Chenoweth	meghan.chenoweth@utoronto.ca	Sex-Dependent Genetic Architecture of Tobacco-Related Biomarkers
26	Natasia S.	Courchesne-Krak	ncourchesne@health.ucsd.edu	Phenome-wide association studies of polygenic liability for externalizing in a European cohort reveals sex- and age-differentiated associations with numerous medical outcomes
27	Richard	Crist	crist@pennmedicine.upenn.edu	Single nucleus ATAC-seq of the central amygdala reveals patterns of chromatin accessibility associated with the cocaine self-administration rats
28	M. Imad	Damaj	m.damaj@vcuhealth.org	Genetic Variation in nicotine withdrawal in mice using reduced complexity cross
29	Giordano	de Guglielmo	gdeguglielmo@health.ucsd.edu	Exploring Genetic Influences on Alcohol Use Disorder: A Comprehensive Study of Addiction-like Behaviors in Heterogeneous Stock Rats
30	Danielle	Dick	danielle.m.dick@rutgers.edu	Characterizing Addiction Risk Across Development in Large Epidemiological and Population-Based Samples
31	Scott R.	Diehl	scott.diehl@rutgers.edu	Strain Differences in Susceptibility to Opioid Side Effects In Female Mice
32	Eamonn	Duffy	Eamonn.duffy@colorado.edu	Sex and genetic background influence intravenous oxycodone self-administration in the Hybrid Rat Diversity Panel
33	Fang	Fang	ffang@rti.org	Exposure- and genetically driven epigenetic associations with lifetime cannabis use.
34	Zoe	Figueroa	zfigu001@ucr.edu	Inflammation driven astrocyte responses during neuroinflammation caused by chronic methamphetamine exposure
35	Heidi S.	Fisher	heidi.fisher@jax.org	Identification of strain differences in transcriptional responses to cocaine across stages of drug self-administration in mice with high and low rates of acquisition and extinction
36	Bryan C.	Quach	bquach@rti.org	Transcriptomic analyses identify genes mediating frequent cocaine use effects on HIV latent reservoir quantity

May 23 – Poster Session B (4:00–5:30 p.m.)
Poster Number	First Name	Last Name	Email	Abstract Title
1	Xiao-Bing	Gao	xiao-bing.gao@yale.edu	Transcriptomic study reveals changes in gene expressions in the lateral hypothalamic area in socially isolated mice: relevance to drug addiction
2	Ivy	Garrenton	igarr001@odu.edu	Dissecting the Etiology of Alcohol Use Disorder by an Integrative Heritable Component Approach
3	Henri M.	Garrison-Desany	hgarrisondesany@hsph.harvard.edu	Association of cord blood DNA methylation patterns and scores with prenatal exposure to opioids, cannabis, and polysubstances
4	Emma	Gnatowski	gnatowskie@vcu.edu	Mechanisms of Ethanol Anxiolysis: Role of Global Ninein Deletion On Ethanol and Anxiety-Like Behaviors.
5	Mikah	Green	mikah.green@som.umaryland.edu	Using a Cas1sf derived system for CRISPR epigenome editing of fentanyl regulated hub genes.
6	Nick	Green	greenni@iu.edu	Cell Type-specific Changes in the Caudate Nucleus of Human Postmortem Brains Induced by Alcohol Use Disorder
7	Benjamin H.	Grissom	Bgrissom@som.umaryland.edu	A single-cell multi-omic atlas of the ventral pallidum reveals VGLUT1 neuron-specific transcriptional responses in immediate and prolonged forced abstinence from heroin self-administration
8	Hongsheng	Gui	hgui1@hfhs.org	Integrative Omics for studying opioid use disorder and suicidality in African Americans
9	Peter	Hamilton	Peter.Hamilton@vcuhealth.org	The function of the ZFP189 transcription factor in the nucleus accumbens facilitates cocaine-specific transcriptional and behavioral adaptations
10	Elaine K.	Hebda-Bauer	hebda@med.umich.edu	The Hippocampus and Nucleus Accumbens Show Unique and Shared Gene Expression Patterns in a Selectively Bred Rat Model of Contrasting Temperaments that Impact Drug Use
11	Hao	Chen	hchen@uthsc.edu	2.) Genetic Association of Socially Acquired Nicotine Self-administration in Adolescent Outbred Rats Identifies Candidate Genes Shared with Human Smoking GWAS
12	Laurens	Holmes, Jr.	lholmes@desu.edu	2.) Aberrant Epigenomic Modulation of Glucocorticoid Receptor Gene (NR3C1) in Substance Use Disorder (SUD) Implicated in Early Life Stress and Major Depressive Disorder (MDD) Correlation
13	Leanne	Holt	leanne.holt@mssm.edu	Astrocytic CREB regulates the transcriptional and behavioral responses to cocaine.
14	Christian	Hopfer	Christian.Hopfer@cuanschutz.edu	Using RNA expression from immune-related cell types in blood to better understand potential influences of THC and CBD on human health
15	Chukwudike	Igwe	chigwe@iu.edu	Is Gm22068 a novel epitranscriptomic marker for thirdhand vaping exposure?
16	Daniel A.	Jacobson	jacobsonda@ornl.gov	Integrating Multi-Omics Data through Multiplex Networks: A Novel Team Science-based Framework for Understanding the Mechanisms Underpinning Substance Use Disorders and Comorbid Neuropsychological Conditions
17	Changhoon	Jee	cjee1@uthsc.edu	Positive reinforcement produced by stimulation of dopaminergic neurons in C. elegans.
18	J. David	Jentsch	jjentsch@binghamton.edu	Heritable differences in incentive motivation are genetically correlated with the excitability of dopamine release in the nucleus accumbens core of inbred mice
19	Emma	Johnson	emma.c.johnson@wustl.edu	2.) Multi-ancestral genome-wide association study of nicotine dependence reveals strong genetic correlations with other substance use and psychiatric disorders
20	Marcus	Kaul	marcus.kaul@medsch.ucr.edu	Chronic, low dose methamphetamine and HIV-1 Tat protein lead to neuronal injury, astrocyte activation and gene expression patterns displaying sexual dimorphism
21	Greg	Keele	gkeele@rti.org	Network biology algorithms identify biological pathways underlying cigarette smoking behaviors
22	Panjun	Kim	pkim11@uthsc.edu	Enhancer-Promoter interactions in rat prefrontal cortex identified by Hi-C sequencing facilitate functional interpretation of genetic association studies on substance abuse traits
23	Brittany	Kuhn	kuhnb@musc.edu	Genome wide association study reveals multiple loci associated with heroin motivation and taking behavior in heterogeneous stock rats
24	Lei	Li	Li129@iit.edu	Cross-modal Sensory Integration: A New Strategy for SUD Treatment
25	Zichong	Li	zichong.li@gladstone.ucsf.edu	Combinatorial Targeting of HIV Transcription: Impact of Cocaine and Morphine on Latency Reactivation
26	Shirelle X.	Liu	liu00459@umn.edu	Common and unique patterns of gene expression and chromatin accessibility in the rat medial prefrontal cortex across different phases of opioid use disorder
27	Falk W.	Lohoff	falk.lohoff@nih.gov	Multi-omics analyses of cortical proteome and single cell-type transcriptome identifies novel drug targets for problematic drinking behavior and alcohol use disorder
28	Andrew	Lombardi	anlo5057@colorado.edu	Role of GSCAN-Identified Genes in the Astrocytic Response to Nicotine
29	Chang	Lu	changlu@vt.edu	Low-input profiling of epigenomic dynamics in mouse brain to understand prolonged synaptic plasticity
30	William	Lynch	wlynch@bu.edu	Validating Zhx2 as a candidate gene underlying Oxycodone Metabolite (Oxymorphone) Brain Concentration and Behavior via Gene Editing and -Omics analyses in BALB/cByJ mice
31	Makoto	Taniguchi	Taniguch@musc.edu	A long non-coding eRNA forms R-loops to shape emotional experience-induced behavioral adaptation
32	Min-Ae	Song	Song.991@osu.edu	A Potential Contribution of Acrylonitrile to Accelerated Epigenetic Aging of the Lungs of Smokers
34	Vivek	Swarup	vswarup@uci.edu	Unraveling Transcriptomic Dynamics: Interplay of Opioid Use Disorder and Early Life Adversity in Distinct Brain Regions

May 24 – Poster Session C (10:20–11:45 a.m.)
Poster Number	First Name	Last Name	Email	Abstract Title
1	Brion	Maher	brion@jhu.edu	Brain Differential Methylation and Gene Expression following Opioid Overdose
2	Lisa	Maturin	lmaturin@health.ucsd.edu	The Addiction Biobanks: Three repositories of biological samples from genetically characterized outbred rats that exhibit compulsive-like escalation of cocaine, oxycodone, and alcohol self-administration.
3	Maria	Mavrikaki	mmavrika@bidmc.harvard.edu	Effects of oxycodone self-administration on gene and microRNA expression
4	Nicola	Micali	nicola.micali@yale.edu	Defining the effects of prenatal cannabinoid exposure on primate fetal brain development
5	Sophia	Miracle	smiracle@bu.edu	Effects of Zhx2 liver and brain overexpression on oxymorphone metabolite levels and state-dependent oxycodone reward learning in BALB/cJ mice with a Zhx2 loss-of-function variant
6	Amy	Moore	almoore@rti.org	Leveraging the All of Us Research Program to Better Understand the Genetic Architecture of Opioid Use Disorder Spectrum Behaviors
7	Anna	Moszczynska	ei2744@wayne.edu	Ubiquitin-Protein Ligase Parkin in Methamphetamine Use Disorder
8	Kateryna	Murlanova	kmurlano@buffalo.edu	Oprm1 deficiency in nucleus accumbens astrocytes increases sensitivity to heroin and reward consumption
9	Nathan	Nakatsuka	08nanaka@gmail.com	A Meta-Analysis Method for Finding Reproducible Differentially Expressed Genes in Single-Cell Transcriptomic Case-Control Studies
10	Jesse	Niehaus	jesse_niehaus@med.unc.edu	Accurately quantifying Oprm1 requires an updated gene annotation.
11	Steve	Oghumu	oghumu.1@osu.edu	Novel approach for the investigation of X-chromosome inactivation in mice exposed to addictive substances
12	Emmanuel	Onaivi	Onaivie@wpunj.edu	Cannabinoid type 2 receptor neuro-immune crosstalk following microglia and dopaminergic neuron specific deletion of CB2Rs.
13	Emily	Orr	eorr@wustl.edu	Applying high throughput deep mutational scanning to study transcription factors implicated in the biology of Substance Use Disorders
14	Abraham A.	Palmer	aap@ucsd.edu	Prescription Opioids Genetic Study (POGS) an innovative instrument for studying the genetic basis traits relevant to opioid use disorder.
15	Yezhi	Pan	ypan@som.umaryland.edu	Nicotine Addiction Functional Networks: A Whole-Brain Connectome Analysis in 24,000 Individuals
16	Ying-Xian	Pan	yx.pan@rutgers.edu	1.) Exploring molecular mechanisms underlying fentanyl overdose-induced toxicities via Oprm1 exon 1-associated variants using tandem mass tag-based phosphoproteomics/proteomics
17	Qian	Peng	qpeng@scripps.edu	Genetic Interactions in Alcohol Use Disorder in a High-Risk Population
18	Roseann E.	Peterson	roseann.peterson@downstate.edu	Expanded Empirical Population Assignments in Biobanks Empower Ancestrally Inclusive Genetic Studies of Substance Use Disorders
19	Chaitanya	Srinivasan	csriniv1@andrew.cmu.edu	Signatures of DNA Damage and Epigenetic Erosion in Opioid Use Disorder
20	Vivek M.	Philip	vivek.philip@jax.org	Systems genetics and genomics data resources from the Center for Systems Neurogenetics of Addiction
21	Marta	Pratelli	mpratelli@ucsd.edu	1.) Dopamine-induced change in transmitter phenotype is a shared mechanism for drug-induced generation of cognitive deficits
22	Elizabeth	Yen	elizabeth.yen2@tuftsmedicine.org	1.) Insulin Sensitivity and Body Composition Effects of Prenatal Opioid Exposure
23	Andrea D.	Raymond	adraymon@fiu.edu	Modulation of microRNA profiles in extracellular vesicles by HIV infection and opiates
24	Walker	Rogers	rogersw@vcu.edu	Investigating Transcriptomic Responses to Ethanol Analgesia Over Time in C57Bl/6J And DBA/2J Mouse Lines
25	Cheryl	Rosenfeld	RosenfeldC@missouri.edu	A Novel Single Nuclei Sequencing Approach to Examine Effects of Oxycodone on Parietal Trophoblast Giant Cells in the Mouse Placenta
26	Pavana	Rotti	protti@wi.mit.edu	Variant Enhancer Loci (VEL) due to Opioid Overdose Impact Forebrain Neuronal Function
27	Laura	Saba	Laura.Saba@cuanschutz.edu	Cell-type specific genetic effects and changes due to oxycodone exposure in RNA expression levels and co-expression networks in rat prefrontal cortex
28	Sandra	Sanchez-Roige	sanchezroige@ucsd.edu	Characterizing cases and controls for opioid use disorders using electronic health records: a phenomic and genomic exploration in over 1 million individuals
29	Pietro Paolo	Sanna	psanna@scripps.edu	Drug self-administration in a rodent model of HIV: from RNA-Seq to druggable targets.
30	Kirti	Sharma	sharmki@iu.edu	One person's nicotine addiction may affect another person's liver
31	Jakob (Koby)	Shaykin	k.shaykin@uky.edu	Genomic Assessment of the Prefrontal Cortex in Differential Responsivity of Sucrose Preference and Fentanyl Escalation in Sprague-Dawley Rats
32	Michael	Sheldon	Michael.Sheldon@sampled.com	The NIDA, ABCD, HBCD, COGA and NESARC Biobanks: Sampled Provides a Critical Resource for Research into the Genetics and Epigenetics of Substance Abuse in Humans
33	Jeremy	Sherman	jeremy.sherman@icahn.mssm.edu	Multimodal RNA-sequencing of the dorsal striatum identifies a link between H3K27 dysregulation and neurodegenerative phenotypes in heroin use.
34	Stephanie	Sillivan	stephanie.sillivan@temple.edu	Integrated analysis of sex-specific regulation of RNA networks in the rat orbitofrontal cortex following heroin self-administration
35	Gabriella	Silva	silvag2@vcu.edu	A zinc finger transcription factor in the nucleus accumbens regulates cocaine-induced transcription and behaviors in a cell type specific manner
36	N. Dalton	Fitzgerald	ndf@uab.edu	Neuronal activation by cocaine varies across molecularly-defined subpopulations of VTA dopamine neurons

May 24 – Poster Session D (2:30–4:00 p.m.)
Poster Number	First Name	Last Name	Email	Abstract Title
1	Madhurbain	Singh	singhm18@vcu.edu	Putative Proximal and Distal Effects between Smoking and Alcohol Consumption: Causal Inference from Models Integrating Polygenic Scores with Longitudinal Data
2	Omar	Soler-Cedeno	omar.soler-cedeno@nih.gov	Dissecting the functional roles of GABAergic vs. glutamatergic neurons in opioid reward using conditional mu opioid receptor-knockout mice
3	Jung Soo	Suk	jsuk@som.umaryland.edu	Combination of focused ultrasound and long-circulating nanoparticles for nucleic acid delivery to the brain
4	Kyle	Sullivan	sullivanka@ornl.gov	Multi-omic integration uncovers biological pathways underlying HIV viral load
5	Jing	Sun	jsun54@jhmi.edu	Reduced level of circulating cell-free nuclear and mitochondrial DNA fragments among Persons who Inject Drugs with HIV
6	Lisa	Tarantino	lisat@med.unc.edu	Repeated exposure to cocaine produces strain specific differences in incentive sensitization in Collaborative Cross mice
7	Zachary	Tatom	tatomz@vcu.edu	Car8 knockout in prefrontal cortex increases voluntary ethanol consumption in male mice
8	Francesca	Telese	ftelese@ucsd.edu	TSS-MPRA to decode regulatory functions of genetic variants associated with substance use disorders.
9	Stella	Tommasi	tommasi@med.usc.edu	Epigenomic dysregulation in youth vapers: implications for disease risk assessment
10	Guy	Twa	gtwa@uab.edu	Accurate sample deconvolution of pooled snRNA-seq using sex-dependent gene expression patterns
11	Mudit	Tyagi	Mudit.Tyagi@jefferson.edu	Cocaine enhances HIV infection, gene expression and replication by stimulating cell metabolism
12	Alp Mete	Umnet	aummet@clemson.edu	Variation in Mushroom Body Morphology in Cocaine Preferring Drosophila Genetic Reference Panel Lines
13	Mary-Elizabeth	Zipparo	mzippar1@jhmi.edu	Past cocaine exposure durably alters CD4+ T-cell reservoir seeding and reactivation SIV-infected ART-suppressed macaques
14	Avinash	Veerappa	aveerappa@unmc.edu	OMICS Perspectives Unveil Neural Circuitry Adaptations in Chronic Heroin Addiction: A Genome-Wide Analysis of Epigenetic Signatures and Transcriptional Programs
15	Thao	Vu	thao.3.vu@cuanschutz.edu	Identification of blood metabolite biomarkers for oxycodone exposure in rats through metabolomics
16	Haohan	Wang	haohanw@illinois.edu	Understanding Variations in Regulatory Networks Across Cell Types through Transformer Model with Knowledge on Regulatory Interactions
17	Bradley T.	Webb	bwebb@rti.org	Deep ascertainment and genetic architecture of alcohol use disorder and related outcomes in All of Us.
18	Julie	White	jdwhite@rti.org	Comparison of DNA methylation signals across substances reveals shared biological implications for substance use
19	Caryn	Willis	cdwillis@rti.org	Meta-analyses of gene expression differences associated with alcohol use disorder in human brain
20	Kelly	Wingfield	kelwing@bu.edu	Exploring mouse ultrasonic vocalizations as a tool to study negative affective states in mice using a mouse model of neonatal opioid withdrawal syndrome (NOWS)
21	Zheng-Xiong	Xi	zxi@intra.nida.nih.gov	Neuronal versus glial CB2 receptor: Findings from a new strain of CB2-KO-EGFP reporter mice
22	Ke	Xu	Ke.Xu@yale.edu	Epigenome-wide characterization reveals aberrant DNA methylation of host genes regulating CD4+ T cell HIV-1 latent reservoir size in women living with HIV
23	Rongguang	Xu	roxu@bwh.harvard.edu	Investigating the Impact of Histone Post-Translational Modifications on Nucleosome Structure and Accessibility: Insights from Molecular Dynamics Studies
24	Ege A.	Yalcinbas	ege.yalcinbas@libd.org	Transcriptomic changes in habenula following chronic fentanyl self-administration in rats
25	Fengchun	Ye	fxy63@case.edu	Nurr-est neighbors: RXR induces epigenetic silencing of HIV-1 in microglial cells
26	Zhenyao	Ye	zye@som.umaryland.edu	Alcohol-Induced Alterations in Brain Functional Connectivity: Insights from Whole-Brain Data-Driven Analysis in Older Adults
27	Marta	Pratelli	mpratelli@ucsd.edu	2.) Pipeline for whole-brain analysis of METH-induced changes in neurotransmitter phenotype
28	Elizabeth	Yen	elizabeth.yen2@tuftsmedicine.org	2.) Molecular Evidence of Sex-Specific Effects in Neonates with Prenatal Opioid Exposure
29	Xinxu	Yuan	Xinxu.yuan@vcuhealth.org	All-in-one AAV delivery of multiplexed hypercompact OsCas12f/sgRNAs to eradicate HIV
30	Zhuzhu	Zhang	zhuzhuzhang@uchicago.edu	Single-Cell Resolution and Circuit-Level Dissection of Epigenomic Remodeling in Addiction
31	Jian	Zhu	jian.zhu@osumc.edu	Contribution of Methamphetamine-Induced Dysregulation of RNA Methylation to Promoting HIV Infection in Microglia/Macrophages
32	Lea	Zillich	lea.zillich@zi-mannheim.de	Cell type-specific multi-omics analysis of cocaine use disorder in the human caudate nucleus suggests phosphodiesterases as a pharmacological target
33	Rajtarun	Madangopal	rajtarun.madangopal@nih.gov	In vivo labeling and molecular characterization of cocaine memory-specific active neurons using the photo-convertible calcium integrator CaMPARI2
34	Katherine	Savell	Katherine.savell@nih.gov	Cell-type-specific transcriptional signatures of cocaine relapse in the rat medial prefrontal cortex

May 2023 Meeting

Welcome

The Genetics and Epigenetics Cross-Cutting Research Team of the National Institute on Drug Abuse invites you to attend the May 16-17, 2023 NIDA Genetics and Epigenetics Cross-Cutting Research Team Meeting at Natcher Auditorium on the NIH Campus in Bethesda, MD. This is an in-person meeting. We expect to have more than 215 scientific presentations.

Meeting Dates and Times

Tuesday, May 16^th: - 9:00 a.m. to 5:30 p.m.
Wednesday, May 17^th - 9:00 a.m. to 5:00 p.m.

Agenda and Meeting Abstracts

May 16 – Keynote (9:15 am – 9:45 am)
Time	First Name	Last Name	Email	Abstract Title
9:15	Andre	Toussaint	at3658@columbia.edu	Understanding Substance Abuse from Scientific and Human Perspectives

May 16 – Session 1 (9:45 am – 11:00 am) - Single cell transcriptional and chromatin profiling of brain reward structures identifies new candidate targets in substance use disorders Eric Nestler and Jeremy Day, Chairs
Time	First Name	Last Name	Email	Abstract Title
9:45	Kristen	Maynard	kristen.maynard@libd.org	Integrated single cell and spatial transcriptomic approaches for defining the molecular anatomy of reward circuitry in the human brain
10:00	Marine	Salery	marine.salery@mssm.edu	Capturing and profiling cocaine-recruited Arc neuronal ensembles encoding drug-context associations in the Nucleus Accumbens.
10:15	Jennifer	Tuscher	jtuscher@uab.edu	Multiomic profiling of the rat nucleus accumbens reveals cell-type specific chromatin remodeling and transcriptional alterations after cocaine experience
10:30	Benjamin	Reiner	bcreiner@pennmedicine.upenn.edu	Single nuclei transcriptomic analysis of rat nucleus accumbens reveals cell type-specific patterns of gene expression associated with volitional morphine

May 16 – Special Presentation (11:00 am – 11:10 am)
Time	First Name	Last Name	Email	Abstract Title
11:00	Anita	Bandrowski	bandrow@gmail.com	RRIDs and where they fit into known standards such as the ARRIVE 2.0 guidelines

May 16 – Session 2 (2:00 pm – 3:00 pm) Artificial Intelligence (AI) Application in Genetics and Epigenomics Carl Lin and Sara Mostafavi, Chairs
Time	First Name	Last Name	Email	Abstract Title
2:00	Carl	Lin	zlin@mclean.harvard.edu	History and Application of Artificial Intelligence: Its Turn for Genomics
2:00	Sara	Mostafavi	saramos@cs.washington.edu	Sequence-based deep learning models for predicting molecular phenotypes
2:15	Hongyang	Li	Hongyang.Li@ibm.com	Asymmetric Predictive Relationships Across Histone Modifications
2:30	Andreas	Pfenning	apfenning@cmu.edu	Fine-mapping candidate neuropsychiatric regulatory variants using cell type-aware comparative genomics

May – 16 Session 3 (4:30 pm – 5:20 pm) - Short Talk Presentations
Time	First Name	Last Name	Email	Abstract Title
4:30	Alexander	Hatoum	ashatoum@wustl.edu	Multivariate genome-wide assocation meta-analysis of 1 million subjects identifies loci underlying multiple substance use disorders
4:40	Jeffrey	Hatfield	jshatfi@g.clemson.edu	Cocaine Preference in the Drosophila melanogaster Genetic Reference Panel
4:50	Chelsie	Benca-Bachman	chelsie.benca@emory.edu	Additive Genetic and Interactive Effects on Alcohol Problems and Traumatic Experiences Among African Americans
4:55	Xiufang (Nadine)	Guo	xguo@mail.ucf.edu	Development of an iPSC-preBötC neuron opiate overdose and recovery multi-organ platform
5:00	Jennifer	Kelschenbach	jennifer.kelschenbach@mssm.edu	Morphine dependence accelerates HIV-associated neurocognitive impairment in EcoHIV infected mice
5:05	Salma	Majid	majidsn@nih.gov	Recurrent and non-recurrent copy number variants in American Indian tribes with substance use disorders
5:10	Freddyson	Martinez-Rivera	freddyson.martinez-rivera@mssm.edu	Cellular and transcriptional contributions of the nucleus accumbens in transferring extinction-based memories
5:15	Evaristus	Nwulia	enwulia@howard.edu	Linking Cannabis Use Disorder, Long-noncoding RNA and Olfactory Structure and Function

May 17 – Session 4 (9:00 am – 10:15 am) - Non-Cannonical regulation of gene-expression by drugs with addictive properties Elizabeth Heller and Zhzhu Zhang, Chairs
Time	First Name	Last Name	Email	Abstract Title
9:00	Elizabeth	Heller	eheller@pennmedicine.upenn.edu	Cocaine regulation of alternative splicing via changes in histone postranslational modifications.
9:15	Zijun	Wang	zjwang@ku.edu	DNA damage and repair processes are involved in opioid addiction
9:30	Zhuzhu	Zhang	zhuzhuzhang@uchicago.edu	Epigenomic remodeling at single cell resolution in cocaine self-administration in mice
9:45	BaDoi	Phan	badoi.phan@pitt.edu	Whole-animal massively parallel reporter assay dissects the region-specific transcriptional impact of human addiction genetic variants

May 17 – Session 5 (1:15 pm – 2:30 pm) - The Role of Behavioral Undercontrol in Mediating Genetic Risk for Substance Use Disorders Abraham Palmer and Danielle Dick, Chairs
Time	First Name	Last Name	Email	Abstract Title
1:15	Holly	Poore	holly.poore@rutgers.edu	Characterizing the Genetic Overlap between Externalizing Phenotypes and Substance Use Disorders
1:30	Sandra	Sanchez-Roige	sanchezroige@ucsd.edu	CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice
1:45	Huda	Akil	akil@umich.edu	Selectively Breeding for Temperament and Vulnerability to Addiction: A Genetic, Genomic and Neural Characterization of Behavioral Undercontrol and Overcontrol.
2:00	Michael	Sheldon	michael.sheldon@sampled.com	Biobanking as a Foundational Component of NIH Research: The NIDA Center for Genetic Studies Provides A Critical Resource for Research into the Genetics and Epigenetics of Substance Abuse

May – 17 Session 6 (4:00 pm – 4:50 pm) - Short Talk Presentations
Time	First Name	Last Name	Email	Abstract Title
4:00	Amrit	Koirala	amrit.koirala@bcm.edu	Deconvolution of microRNA/mRNA Networks in Brain Regions Impacted by Cocaine Use Disorder to Develop a Mechanistic Biosignature for Pharmacotherapy Response
4:10	Vivek	Philip	Vivek.Philip@jax.org	Enumeration and visualization of differential gene co-expression response to cocaine
4:20	Janitza	Montalvo-Ortiz	janitza.montalvo-ortiz@yale.edu	Deciphering the role of DNA hydroxymethylation in substance use disorders
4:25	MadhurBain	Singh	singhm18@vcu.edu	Examining Bidirectional Causal Effects between Smoking and DNA Methylation using Epigenetic Mendelian Randomization Analyses
4:30	Alyssa	Wilson	alyssa.wilson@mssm.edu	Identifying Cell-Type-Specific Transcriptional Changes in Midbrain in the Context of Substance Use Disorder and Long-Term HIV Infection: A Cohort Study at the Manhattan HIV Brain Bank
4:35	Francesca	Telese	ftelese@health.ucsd.edu	Analysis of single nuclei RNA-seq from the nucleus accumbens of heterozygous reeler mice exposed to THC during adolescence suggests a link between THC exposure, Reelin signaling, and vulnerability to human psychiatric disorders
4:40	Jared	Bagley	jbagley@binghamton.edu	Neuron navigator 1 regulates the self-administration of cocaine
4:45	Laura	Saba	Laura.Saba@cuanschutz.edu	Multi-omic single nuclei data provide insight into the cellular origin of whole brain coexpression patterns related to Oprm1

May 16 – Poster Session A (11:10 am – 12:40 pm)
Poster #	First Name	Last Name	Email	Abstract Title
1	Arpana	Agrawal	arpana@wustl.edu	The Psychiatric Genomics Consortium Substance Use Disorders Working Group (PGC-SUD): An Update
2	Schahram	Akbarian	schahram.akbarian@mssm.edu	Single Nucleus Transcriptomic Profiling of Human Ventral Midbrain Reveals Widespread Activation of Multiple Glial Subtype
3	Muhammad	Arshad	muhammadwaqar.arshad@yale.edu	Substance Abuse in Pakistan: Clinical Issues and Research Opportunities
4	Bao-Zhu	Yang	bao-zhu.yang@yale.edu	Inter-Linking the Developmental Brain Transcriptome and GWAS Risk Variants Revealed Neural Circuits Prognostic of Nicotine Use Severity
5	David	Ashbrook	dashbrook@UTHSC.edu	Good wine and old data get better with age: New insights on gene-by-environment effects of drugs of abuse in mice using GeneNetwork.org
6	Christopher	Baker	christopher.baker@jax.org	Genetic variation influences cell specific cis-regulatory landscape in the mouse striatum
7	Madelyn	Baker	mrb4002@med.cornell.edu	Epigenetic representation of cocaine-context association in the dorsal dentate gyrus of male mice
8	Britahny	Baskin	britty@bu.edu	Premorbid addiction model traits and cocaine stimulant sensitivity in spontaneously hypertensive rat (SHR) substrains
9	Jacob	Beierle	Jacob.Beierle@jax.org	A high-throughput machine vision-based univariate scale for pain and analgesia in mice
10	Aritra	Bhattacherjee	writetoab@gmail.com	Decoding molecular organization of the brain reward circuit for understanding mechanisms of drug addiction
11	Chuan	Bi	chuan.bi@som.umaryland.edu	Multivariate Mediation Analysis of Genetic Variants, Brain Connectome and Nicotine Addiction
12	Fatah	Kashanchi	fkashanc@gmu.edu	Retroviral infection of human neurospheres and use of stem cell EVs to repair cellular damage
13	Kasey	Brida	kbrida@uab.edu	Reelin protein marks cocaine-sensitive Drd1+ medium spiny neurons and modulates medium spiny neuron physiology and behavioral response to cocaine
14	Russell	Brown	BROWN1@mail.etsu.edu	Analysis of the enhanced rewarding effects of nicotine and underlying neuroplasticity mechanisms in a heritable model of drug abuse vulnerability in psychosis
15	Caleb	Browne	caleb.browne@mssm.edu	Transcriptome profiling of the brain’s reward circuitry in heroin self-administration identifies a ventral hippocampus gene network related to relapse susceptibility
16	Edward	Browne	epbrowne@email.unc.edu	Defining the impact of cannabis use on immune cell phenotypes and the latent viral reservoir in people with HIV.
17	Camron	Bryant	camron@bu.edu	Spectrotemporal USV profiles during neonatal opioid withdrawal in FVB substrains, Zhx2-edited BALB/c substrains, and outbred CFW mice
18	Jason	Bubier	Jason.Bubier@jax.org	A Tale of Two Opioids: The Genetics of Opioid Induced Respiratory Depression in Response to Fentanyl and Morphine in Mice.
19	Belle	Buzzi	buzzib@vcu.edu	Nicotine reward and preference in C57BL/6J and C57BL/6N mouse strains
20	Jean Lud	Cadet	jcadet@intra.nida.nih.gov	Compulsive methamphetamine intake and abstinence in the presence of punishment are associated with differential hydroxymethylation of miRNAs in the rat nucleus accumbens
21	Cali	Calarco	ccalarco@som.umaryland.edu	Mitochondrial gene ontology pathways and transcriptional regulators impacted by cocaine in C57Bl/6 mice
22	Rianne	Campbell	rcampbell@som.umaryland.edu	Baseline Characterizations of Novel D1R-CRISPRa and A2A-CRISPRa Mouse Lines
23	Javan	Carter	JCarter@rti.org	Identifying novel genes and pathways associated with opioid overdose death via meta-analysis of differential gene expression.
24	Samantha	Cheeks	scheeks@uci.edu	Cannabidiol Attenuates Nicotine Self-Administration and Withdrawal Symptomology in Mice
25	Jixin	Chen	chenj@ohio.edu	A single-molecule FRET data fitting package for DNA folding kinetic study
26	Yong	Chen	chenyong@rowan.edu	Inferring Memory-related Regulatory Modules in Engram Cells by Deep-learning and scRNA-seq Data
27	Olivia	Corradin	corradin@wi.mit.edu	Case-specific epigenetic alterations converge on key genes linked to opioid overdose
28	Daniel	Wood	woodda@musc.edu	HDAC5 intrinsic enzymatic activity limits drug-seeking behavior
29	Santiago	Cuesta	santiago.cuesta@rutgers.edu	Gut Microbiota Composition Modulates Cocaine-Induced Neurobehavioral Plasticity
30	Eamonn	Duffy	Eamonn.Duffy@colorado.edu	Characterization of thermal and mechanical sensitivity in select strains of the Hybrid Rat Diversity Panel
31	Soren	Emerson	soren.d.emerson@vanderbilt.edu	Lysine acetyltransferase KAT2a is a novel cocaine-recruited epigenetic regulator in the nucleus accumbens
32	Dan	Fabris	dan.fabris@uconn.edu	Investigating epitranscriptomic communications between HIV-1 infection and neuromodulator response in different CNS cells
33	Fang	Fang	ffang@rti.org	A DNA methylation-based classifier for lifetime cannabis use
34	J. Adam	Fields	jafields@health.ucsd.edu	Effects of cannabinoids on phenotype of patient monocyte-derived macrophages vary by cannabis use patterns
35	Zoe	Figueroa	zoe.figueroa@email.ucr.edu	Astrocytic contributions to chronic methamphetamine induced neuroinflammation and disease
36	Prescilla	Garcia-Trevizo	pjg5435@psu.edu	Long-term Effects of Adolescent Nicotine Exposure on Sensitivity and Cotinine in the Diversity Outbred Mouse Population.
37	Paige	Lemen	plemen1@uthsc.edu	Adolescent Social Isolation Increases Vulnerability to Voluntary Opioid Consumption in Adulthood in Rats
38	Mudit	Tyagi	Mudit.Tyagi@jefferson.edu	Cocaine by co-stimulating NF-kB, NFAT, and AP-1 enhances CD4+ T-cells metabolism; thus, sensitizes partially active cells for HIV infection
39	Min-Ae	Song	song.991@osu.edu	Epigenetic Aging in the Human Lung: Focus on Smoking and Vaping

May 16 – Poster Session B (3:00 pm – 4:30 pm)
Poster #	First Name	Last Name	Email	Abstract Title
1	Vivek	Swarup	vswarup@uci.edu	Investigating multi-omic Mechanisms Underlying Opioid Addiction Vulnerability: A Multi-Omics Study
2	Colin	Hodgkinson	chodg@mail.nih.gov	Alcohol and stress additively accelerate epigenetic cellular age
3	Rodrigo	Grassi-Oliveira	rogo@clin.au.dk	Exposomics of Cocaine Use Disorder: A new paradigm to study the impact of environmental exposures in Substance Use Disorders
4	Benjamin	Grissom	BGrissom@som.umaryland.edu	Heroin-induced genomic regulation of ventral pallidum and nucleus accumbens neuron subtypes
5	Petar	Grozdanov	petar.grozdanov@ttuhsc.edu	The role of alternative polyadenylation in a TLR3-mediated mouse model of escalated alcohol consumption
6	Hongsheng	Gui	hgui1@hfhs.org	Bivariate relationship between opioid use disorder and suicide attempts despite mental health
7	Megan	Hagenauer	hagenaue@umich.edu	The Brain Data Alchemy Project: Teaching Research Reproducibility and Discovery Science While Mining Gold from Archived Genomics Data
8	Nikhil	Hajirnis	nhajirnis@som.umaryland.edu	Epigenomic editing of nucleus accumbens neuron subtypes using the CRISPR-Cas12f derived system
9	Peter	Hamilton	peter.hamilton@vcuhealth.org	Synthetic transcription factors, delivered to mouse nucleus accumbens, dysregulate drug-specific transcription and behaviors
10	Shuanglin	Hao	shao@med.miami.edu	Loss of Sirt3 induced by HIV gp120 with morphine in neuropathic pain, is mediated by H3K27me3 in the spinal cord
11	Emily	Hartwell	Emily.Hartwell@pennmedicine.upenn.edu	Performance of a polygenic risk score for depression in a deeply phenotyped sample
12	Ying	He	yhe@midwestern.edu	Epigenetic regulation of opioid dependence by microRNAs
13	Elaine	Hebda-Bauer	hebda@med.umich.edu	Bioenergetic-Related Gene Expression in the Hippocampus Predicts Internalizing vs. Externalizing Behavior in a F2 Cross of Selectively-Bred Rats
14	Ming-Fen	Ho	ho.mingfen@mayo.edu	Epigenetic Regulation of GABA Catabolism in iPSC-derived Neurons: the Role of FGF21
15	Leanne	Holt	leanne.holt@mssm.edu	Elucidation of the astrocyte-specific transcriptome following cocaine self-administration
16	Spencer	Huggett	shuggett91@gmail.com	In Silico Genetic & Neuromolecular Drug Repurposing for Opioid Use Disorder
17	Alvin	Jeffery	alvin.d.jeffery@vanderbilt.edu	Detecting Opioid Use Disorders in the Electronic Health Record to Support Genetic Studies: Adaptation of the Addiction Behaviors Checklist
18	Thomas	Jhou	jhou@musc.edu	Heritability and GWAS analyses of punishment sensitivity and cocaine avoidance in HS rats
19	Kan	Shao	kshao@indiana.edu	Dose-Response Analysis to Advance Gene and Pathway Identification for Risk Estimation of Substance Use Disorder
20	Guochun	Jiang	jianggc@gmail.com	Epigenetic regulation of a persistent HIV reservoir in human brain myeloid cells despite durable ART
21	Emma	Johnson	emma.c.johnson@wustl.edu	Cross-disorder analysis of cannabis use disorder and schizophrenia reveals convergent and divergent genetic influences
22	Yonwoo	Jung	yonwoo.jung@nih.gov	Mitochondrial Dysfunction and Oxidative Stress: Conserved Functional Phenotypes in Cocaine Addiction across Multiple Brain Regions
23	Marcus	Kaul	Marcus.Kaul@medsch.ucr.edu	Methamphetamine promotes in macrophages stimulated with LTR mimic ssRNA40 expression of HIV-regulating lncRNA HEAL and pro-inflammatory factors but suppresses the interferon response
24	Panjun	Kim	pkim11@uthsc.edu	3D Chromatin Interaction Data Facilitates de novo Genome Assembly and Identifies Promoter-Enhancer Interaction in the PFC of Rats
25	Cassandra	Kooiker	ckooiker@uci.edu	Genetic tagging uncovers a role for the thalamic paraventricular nucleus in mediating aberrant reward behaviors following adverse experiences early in life
26	Brittany	Kuhn	kuhnb@musc.edu	Network-based clustering approach models multi-symptomatic opioid use disorder vulnerability
27	Ashley	Kumar	avkumar@ucsd.edu	Transcriptional initiation profiling of primary brain cells to study stimulus-dependent enhancer activity
28	Valeria	Lallai	vlallai@uci.edu	THC- and Nicotine-Induced Changes in Central and Peripheral Extracellular Vesicle RNA Cargo
29	Eva	Lancaster	Eva.Lancaster@vcuhealth.org	Examining polygenic risk score by environment interaction on the relationship between interpersonal violence exposure and alcohol use in an ancestrally diverse college cohort
30	Paige	Lemen	plemen1@uthsc.edu	Opiate responses are controlled by interactions of Oprm1 and Fgf12 loci in rodents: Correspondence to human GWAS findings
31	Michael	Leone	mleone@andrew.cmu.edu	Spinal cord neuronal subtypes conserved across species are genetically implicated in chronic pain disorders
32	Dongmei	Li	Dongmei_Li@urmc.rochester.edu	Longitudinal changes in expression profile of urine exosomal epigenetic microRNAs in exclusive electronic cigarette adult users
33	Xiaoyu	Liang	xiaoyuliang@msu.edu	DNA Methylation-Based Telomere Length Is Associated With HIV Frailty and All-Cause Mortality
34	Carl	Litif	clitif@uwyo.edu	Identifying reward-specific transcriptomes underlying polyreward seeking ensembles in the nucleus accumbens core and prelimbic cortex
35	Shirelle	Liu	liu00459@umn.edu	Differential gene expression and epigenetic regulation in the medial prefrontal cortex of rats showing vulnerability to opioid addiction
36	Jennifer	Loftis	loftisj@ohsu.edu	Plasma extracellular vesicles and their miRNA cargo as biosignatures for neuropsychiatric impairments in methamphetamine use disorders
37	Ryan	Logan	Ryan.Logan@umassmed.edu	Elevated DNA damage and inflammatory markers in specific striatal cell types associated with opioid use disorder using single nuclei RNAseq in human postmortem brain
38	Falk	Lohoff	falk.lohoff@nih.gov	Additive Effects of Stress and Alcohol on Epigenetic Aging
39	Samikkannu	Thangavel	thangavel@tamu.edu	Epigenetic signature of N-terminal acetyltransferases role in HIV-Neuropathogenesis

May 17 – Poster Session C (10:15 am – 11:45 am)
Poster #	First Name	Last Name	Email	Abstract Title
1	Alice	Min	Alice.Min@mountsinai.org	A novel humanized mouse model to track active and latent CNS HIV-1 infection and to test therapeutic interventions
2	Luis	Araujo	ldearaujo@unimelb.edu.au	Power, measurement error and pleiotropy robustness in twin design extensions to Mendelian randomization
3	Paige	Lemen	plemen1@uthsc.edu	Oxycodone oral self-administration in inbred rats identifies different patterns of vulnerability
4	Andrew	Lombardi	anlo5057@colorado.edu	Role of GSCAN Identified Genes in the Astrocytic Response to Nicotine
5	Shahrdad	Lotfipour	shahrdadlotfipour@me.com	Functional Role of a Human 3'UTR Alpha6 Nicotinic Receptor Polymorphism (rs2304297) in Adolescent Substance Use
6	Qing	Lu	lucienq@ufl.edu	Kernel Neural Networks for Analyzing Large-scale Substance Use Disorders Genetic Data
7	William	Lynch	wlynch@bu.edu	Validating Zhx2 in oxycodone metabolite (oxymorphone) brain concentration and behavior via reciprocal gene editing and viral manipulation of gene expression in BALB/c substrains
8	Tianzhou	Ma	tma0929@umd.edu	Bayesian indicator variable selection for multivariate response with application to multi-trait fine mapping
9	Scott	Mackey	msmackey@uvm.com	ENIGMA Addiction: Neuroimaging Biotypes Supported by Gene Enrichment Analysis
10	Rajtarun	Madangopal	rajtarun.madangopal@nih.gov	In vivo labeling and molecular characterization of cocaine memory-specific active neurons using the photo-convertible calcium integrator CaMPARI2
11	Travis	Mallard	tmallard@mgh.harvard.edu	Limited evidence for a general dimension of impulsivity across genomic, transcriptomic, and neuroanatomical levels of analysis
12	Lisa	Maturin	lmaturin@health.ucsd.edu	The Addiction Biobanks: : Three repositories of biological samples from genetically characterized outbred rats that exhibit compulsive-like escalation of cocaine, oxycodone, and alcohol self-administration.
13	Nicola	Micali	nicola.micali@yale.edu	The effect of prenatal cannabinoid exposure on developing primate cerebrum
14	Melyssa	Minto	mminto@rti.org	Tissue-Specific DNA Methylation Signatures of Alcohol Use Disorder in Human Brain
15	Suzanne	Mitchell	mitchesu@ohsu.edu	Lessons learned in creating selected lines for high and low delay discounting
16	Mahesh	Mohan	mmohan@txbiomed.org	Delta-9-Tetrahydrocannabinol:Cannabidiol combination counteracts colonic epithelial and blood-brain barrier dysfunction in SIV-infected rhesus macaques on combination anti-retroviral therapy
17	Kateryna	Murlanova	kmurlano@buffalo.edu	Loss of astrocytic mu opioid receptors exacerbates aversion associated with morphine withdrawal in mice: a role for mitochondrial respiration
18	Randy	Nelson	randy.nelson@hsc.wvu.edu	Light at Night Drives Sex-Specific Increases in Fentanyl Reward-Related Behaviors
19	Abraham	Palmer	aap@ucsd.edu	RATTACA: a new paradigm for examining genetic correlations in outbred rats
20	Rohan	Palmer	Rohan.Palmer@Emory.edu	Conserved Co-expression Signatures of Chronic Alcohol Consumption across Species
21	Clarissa	Parker	cparker@middlebury.edu	Genetic variation and heritability of negative affective withdrawal from cocaine in the CC/DO founder mouse strains
22	Gita	Pathak	gita.pathak@yale.edu	Epigenetic profiles of latent classes for polysubstance use disorder
23	Jack	Pattee	jack.pattee@cuanschutz.edu	Adjusting for cis-regulatory variation in gene expression data can improve biological network analysis in model organisms
24	Qian	Peng	qpeng@scripps.edu	Pleiotropic Loci for Cannabis Use Disorder Severity in Multi-Ancestry High-Risk Populations
25	Inga	Peter	inga.peter@mssm.edu	High Content Transcriptomics Screen to Explore Pathway Crosstalk between Morphine and Antiretroviral Therapy Drug Combinations
26	Amanda	Gentry	Amanda.Gentry@vcuhealth.org	Machine Learning to Predict Alcohol Consumption From Blood-Based Biomarkers
27	Robert	Phillips	rphill3@uab.edu	Distinct subpopulations of D1 medium spiny neurons exhibit unique transcriptional responsiveness to cocaine
28	Bryan	Quach	bquach@rti.org	Transcriptome-wide association study for frequent cocaine use identifies gene dysregulation in CD4+ T cells linked to immune response and cancer pathways
29	Fatir	Qureshi	qureshi@wi.mit.edu	Chromatin QTL analysis identifies genetic variants that influence H3K27ac in opioid overdose cases.
30	Yumna	Rahman	rahmany@vcu.edu	Influence of Genotype and Sex on Oral Nicotine Consumption in Founder Strains of Diversity Outbred Mice
31	Hannah	Ramcharan	hkramcha@wi.mit.edu	Variation in Gene Regulation Across Neurons from Seven Different Brain Regions
32	David	Root	David.Root@Colorado.EDU	Ventral tegmental area glutamate neurons establish a mu-opioid receptor gated circuit to mesolimbic dopamine neurons and regulate opioid-seeking behavior
33	Adrian	Rothenfluh	adrian.rothenfluh@hsc.utah.edu	Bitter gustatory perception protects Drosophila from escalating cocaine consumption preference.
34	Erick	Saldes	esaldes@miners.utep.edu	Novel genetic loci interacting with social environment for dysfunctional inhibitory control
35	Danielle	Sambo	danielle.sambo@nih.gov	Differential effects of prenatal alcohol exposure on brain growth in a mouse model for fetal alcohol spectrum disorder
36	Yasmine	Sami	yns@wi.mit.edu	Differentially expressed genes in Opioid Use Disorder are enriched amongst genes with brain region specific regulatory activity
37	Jiangwen	Sun	jsun@odu.edu	Training Deep Neural Networks Predicting DNA Methylation to Elucidate Genetic Associations in Substance Use Disorders

May 17 – Poster Session D (2:30 pm – 4:00 pm)
Poster #	First Name	Last Name	Email	Abstract Title
1	Sandra	Sanchez-Roige	sanchezroige@ucsd.edu	Multi-ancestry meta-analysis of tobacco use disorder based on electronic health record data prioritizes novel candidate risk genes and reveals associations with numerous health outcomes
2	Pietro	Sanna	psanna@scripps.edu	Unraveling the interplay between neuroHIV and substance abuse with systems biology to shed light on novel druggable targets.
3	Katherine	Savell	katherine.savell@nih.gov	Development of multipleXed Population Selection and Enrichment single nuclei RNA-sequencing (XPoSE-seq) to characterize neuronal ensembles in cocaine relapse
4	Randal Alex	Serafini	alex.serafini@icahn.mssm.edu	Novel Oxycodone Paradigm Highlights Mesocorticolimbic Mechanisms Underpinning Withdrawal-associated Behaviors with and without Chronic Pain
5	Marit	Solheim-Witt	marit@alpha-element.com	Resilience, resourcefulness and self-leadership: Evaluation of a self-management program and novel conceptual framework of Vitality Type patterns in behavior and communication
6	Akhil	Sharma	akhilsharma@wayne.edu	Comparing Responses of the Nucleus Accumbens and Ammon’s Horn to Methamphetamine Neurotoxicity
7	Aliaksandra	Sikirzhytskaya	sikirzha@mailbox.sc.edu	AI-based mining of biomedical literature: Applications for the drug repurposing for the treatment of HIV-Associated Neurocognitive Disorder.
8	Omar	Soler-Cedeño	omar.soler-cedeno@nih.gov	Brain CB2 receptor: a new therapeutic target for treating opioid use disorders, major findings from a new CB2-KO-eGFP reporter mouse line
9	Sheetal	Sreeram	sxs2286@case.edu	Induced pluripotent stem cells (iPSCs) derived cerebral organoids to model the impact of methamphetamine exposure on HIV latency.
10	Chaitanya	Srinivasan	csriniv1@cs.cmu.edu	Regulatory variation in D1/D2 co-expressing medium spiny neurons is suggested to predispose addiction-related traits
11	Jerry	Stitzel	stitzel@colorado.edu	QTL Mapping of Genetic Modifiers of Oral Nicotine Consumption in Chrna5 Null Mutant Mice
12	Kyle	Sullivan	sullivanka@ornl.gov	Heroin overdose-associated transcriptional and epigenetic alterations in the orbitofrontal cortex concentrate in GABAergic interneurons and provide insight into cell type-specific regulatory response
13	Jiangwen	Sun	jsun@odu.edu	Annotating Genetic Variants by Training Deep Neural Networks to Predict Multiple Epigenomic Events in Brain via Effective Multi-task Learning
14	Makoto	Taniguchi	Taniguch@musc.edu	A long non-coding enhancer RNA regulates NPAS4 in the NAc to control drug reward-conditioned behavior
15	Lisa	Tarantino	lisat@med.unc.edu	Genetic mapping of initial locomotor sensitivity to cocaine in two divergent Collaborative Cross inbred mouse strains
16	Iris	Titos	iris.titos@utah.edu	Mechanisms of diet modulating experience-dependent amphetamine preference
17	Jill	Turner	Jill.Turner@uky.edu	Phenotyping Individual Differences in Escalation of Fentanyl Self-Administration in Sprague-Dawley Rats.
18	David	Vandenbergh	djv4@psu.edu	Hyper-Variable Number of Tandem Repeats in Intron 8 of the Human Dopamine Transporter Gene (SLC6A3)
19	Arvind	Venkataraman	avenkata@uw.edu	A genome-wide association study of methamphetamine use among people with HIV
20	Thiago	Viola	thiago.wendt.viola@gmail.com	The effects of maternal cocaine use during pregnancy in pediatric epigenetic clocks and methylation risk scores in humans
21	Lu	Wang	lu.wang.lw763@yale.edu	Whole-exome Sequencing Study of Alcohol Use Disorder in 1,668 European Americans and 1,547 African Americans
22	Xu	Wang	xuwang@temple.edu	Activation of Toll-like receptor 3 by poly (I:C) inhibits HIV infection of human iPSC-derived microglia
23	Tao	Wu	Tao.Wu@bcm.edu	Quantitative Profiling of DNA N6-methyladenine at single-base resolution with NAME-Seq
24	Sarah	Neal	sjneal@mdanderson.org	A Baboon Research Resource for Use in Studies on Substance Abuse Disorders
25	Julie	White	jdwhite@rti.org	Integration of DNA methylation and RNA sequencing elucidates differential gene regulation associated with alcohol use disorder in the human brain
26	Anastasia	Williams	awill57@gmu.edu	The effects of cannabidiol and HU308 on viral transcription in HIV-1 infected cells and resulting extracellular vesicle release
27	Caryn	Willis	cdwillis@rti.org	Gene Correlation Networks Replication Analysis Across Studies to Identify Top Candidate Gene Targets in Opioid Use Disorder
28	Michael	Wyatt	wyatt@cop.sc.edu	Drug Repurposing for the prevention of dementia among people living with human immunodeficiency virus: A focus on the renin-angiotensin system
29	Rong-Guang	Xu	roxu@bwh.harvard.edu	How histone post-translational modifications impact nucleosome structure and accessibility: A molecular dynamics study
30	Gal	Yadid	yadidg@mail.biu.ac.il	Use of psychedelic and epigenetic substances as novel approaches for treating substance addiction – hope or hype?
31	Zhenyao	Ye	zye@som.umaryland.edu	Pleiotropic genes for resting-state brain functional connectivity and nicotine addiction
32	Hang	Zhou	hang.zhou@yale.edu	Mendelian Randomization Analysis of the Effects of Alcohol Use on Cancer Risk
33	Yanjiao	Zhou	yazhou@uchc.edu	Genetic control of the microbiome and bile acids to influence addiction-related behaviors
34	Laura	Hack	hack@stanford.edu	Ketamine’s Acute Effects on Negative Brain States are Mediated through Distinct Altered States in Humans
35	Yanchao	Pan	hanyou@umich.edu	A revamped rat reference genome improves the discovery of genetic diversity of laboratory rats

Abstracts From Those Unavailable to Present
First Name	Last Name	Email	Abstract Title
Li-Shiun	Chen	li-shiun@wustl.edu	Roadmap for translating genomic evidence to clinical interventions for prevention and treatment
Ditte	Demontis	ditte@biomed.au.dk	Elucidating genetic risk factors for externalizing and internalizing alcohol use disorder behaviors through large-scale cross-disorder GWAS
Desmond	Smith	DSmith@mednet.ucla.edu	Cocaine and cannabis: a joint dependence revealed by a longitudinal genetic study in mice

Past Genetic Meetings are available on the Archives site

May 8, 2024